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PET-based immunomapping of intratumoral CD4+ cells to monitor acquired resistance to checkpoint inhibitors

Sci Adv

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Scientific articles

Lack of GDAP1 Induces Neuronal Calcium and Mitochondrial Defects in a Knockout Mouse Model of Charcot-Marie-Tooth Neuropathy

PloS Genetics

Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase.

Proc Natl Acad Sci U S A

Development of Congenital Stromal Corneal Dystrophy Is Dependent on Export and Extracellular Deposition of Truncated Decorin

Invest Ophthalmol Vis Sci

Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis.

Circulation

Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-induced Expression of RANKL.

Endocrinology

The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.

Am J Physiol Regul Integr Comp Physiol

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.

J Biol Chem

The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain.

Brain Res

The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis.

J Clin Invest

The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/b-Catenin Signaling

Dev Cell

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

Nat Commun

Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.

Hum Mol Genet

NTPDase2 and Purinergic Signaling Control Progenitor Cell Proliferation in Neurogenic Niches of the Adult Mouse Brain

Stem Cells

NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation.

Free Radic Biol Med

Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification

J Bone Miner Res

Myofibrillar instability exacerbated by acute exercise in filaminopathy

Hum Mol Genet

Musclin is an activity-stimulated myokine that enhances physical endurance.

Proc Natl Acad Sci U S A

Molecular genetic regulation of Slc30a8/ZnT8 reveals a positive association with glucose tolerance.

Mol Endocrinol

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.

PLoS One

Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice

PLoS One

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin.

J Exp Med

In vivo structure‐function studies of human hepatic lipase: the catalytic function rescues the lean phenotype of HL‐deficient (hl−/−) mice

Physiol Rep

Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner

Proc Natl Acad Sci U S A

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.

J Exp Med

Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.

J Exp Med

Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin.

J Immunol

Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide..

J Immunol

Deletion of the Distal Tnfsf11 RL-D2 Enhancer that Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice.

J Bone Miner Res

Critical roles for WDR72 in calcium transport and matrix protein removal during enamel maturation

Mol Genet Genomic Med

Clic4, a novel protein that sensitizes β-cells to apoptosis.

Mol Metab

CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span.

Chem Senses

Brain Serotonin Signaling Does Not Determine Sexual Preference in Male Mice

PLoS One

Altered lymphopoiesis and immunodeficiency in miR-142 null mice.

Blood

Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats.

Eur J Pharmacol

Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells

Mol Cell Biol

Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases

Genome Res.

The regulatory T cells induction by Epicutaneous immunotherapy is sustained and mediates long term protection from eosinophilic disorders in peanut sensitized mice

Clin Exp Allergy

PILRα negatively regulates mouse inflammatory arthritis

J Immunol

Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.

ACS Chem Neurosci

Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis

Mucosal Immunol

Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice

Lab Invest

Knock-In of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like Phenotypes

J Neurosci

Cerebral Cortex Hyperthyroidism of Newborn Mct8- Deficient Mice Transiently Suppressed by Lat2 Inactivation

PLoS One

Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment

Cell Death Differ

AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: Implications for myocardial differentiation and regional identity

Dev Biol

Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin

J Appl Physiol (1985)

Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis

J Clin Invest

The toxic effect of R350P mutant desmin in striated muscle of man and mouse

Acta Neuropathol

The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus

Cell Metab

The iFat1 transgene permits conditional endogenous n-3 PUFA enrichment both in vitro and in vivo

Transgenic Res

Serotonin Reuptake Transporter Deficiency Modulates the Acute Thermoregulatory and Locomotor Activity Response to 3,4-({+/-})-Methylenedioxymethamphetamine, and Attenuates Depletions in Serotonin Levels in SERT-KO Rats

Toxicol Sci

Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation.

Cell Rep

Salty Taste Deficits in CALHM1 Knockout Mice

Chem Senses

RIP3 induces apoptosis independent of pronecrotic kinase activity

Mol Cell

RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

J Immunol

Relevance of Nck-CD3{varepsilon} Interaction for T Cell Activation In Vivo.

J Immunol

Phenotypic Characterization of miR-92a2/2 Mice Reveals an Important Function of miR-92a in Skeletal Development

PLoS One

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis.

Development

Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson’s disease triggered by mitochondrial stress

Neuropharmacology

Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury.

Cardiovasc Res

Ins1 Cre knock-in mice for beta cell-specific gene recombination

Diabetologia

IG20/MADD Plays a Critical Role in Glucose-Induced Insulin Secretion

Diabetes

Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo

Blood

Glycogen storage disease type III: A novel Agl knockout mouse model

Biochim Biophys Acta

DRAGO (KIAA0247), a New DNA Damage-Responsive, p53-Inducible Gene That Cooperates With p53 as Oncosupprossor.

J Natl Cancer Inst

Effect of light on global gene expression in the neuroglobin-deficient mouse retina

Biomedical Reports

Endothelial C-type natriuretic peptide maintains vascular homeostasis.

J Clin Invest

Disturbances in cholesterol, bile acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase B deficient mice fed diets containing high or low fat contents

Biochimie

Differential Expression and Function of Nicotinic Acetylcholine Receptors in Subdivisions of Medial Habenula

J Neurosci

Conditional disruption of interactions between Gαi2 and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury

BMC Pharmacology and Toxicology

Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis

J Mol Med

Changes in neural network homeostasis trigger neuropsychiatric symptoms.

J Clin Invest

CCN2 expression by fibroblasts is not required for cutaneous tissue repair.

Wound Repair Regen

Brain serotonin determines maternal behavior and offspring survival.

Genes Brain Behav

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.

Science

ALKBH4 Depletion in Mice Leads to Spermatogenic Defects

PLoS One

Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse

Mol Vis

A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice.

Am J Respir Cell Mol Biol

A conditional knockout mouse model reveals endothelial cells as the predominant and possibly exclusive source of plasma factor VIII

Blood

XBP1 mRNA Splicing Triggers an Autophagic Response in Endothelial Cells through BECLIN-1 Transcriptional Activation.

J Biol Chem

Visceral hypersensitivity in female but not in male serotonin transporter knockout rats.

Neurogastroenterol Motil

The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model

Blood

Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent.

Cell Mol Life Sci

Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice

PLoS One

Paneth cells as a siteoforigin for intestinal inflammation

Nature

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

J Clin Invest

Nitric oxide regulates cardiac intracellular Na+ and Ca2+ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism.

J Mol Cell Cardiol

Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice

Am J Hum Genet

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

J Vis Exp

Inhibition of MicroRNA-92a Protects Against Ischemia-Reperfusion Injury in a Large Animal Model.

Circulation

Helicase-like transcription factor (hltf) regulates g2/m transition, wt1/gata4/hif-1a cardiac transcription networks, and collagen biogenesis.

PLoS One

Differential modulation of EAE by α9-and β2-nicotinic acetylcholine receptors

Immunol Cell Biol

Deletion of mouse Alkbh7 leads to obesity.

J Mol Cell Biol

CALHM1 controls Ca2+-dependent MEK/ERK/RSK/MSK signaling in neurons.

J Cell Sci

Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs

Nat Med

Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis

Circulation

Visualising Androgen Receptor Activity in Male and Female Mice

PLoS One

Unexpected CEP290 mRNA Splicing in a Humanized Knock-In Mouse Model for Leber Congenital Amaurosis

PLoS One

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

Diabetologia

The Tissue-Specific RNA Binding Protein T-STAR Controls Regional Splicing Patterns of Neurexin Pre-mRNAs in the Brain

PloS Genetics

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