This study investigates the role of regulatory T cells (Tregs) in the efficacy of epicutaneous immunotherapy (EPIT) for peanut allergy. Using a BALB/c mouse model sensitized to peanut proteins, the researchers demonstrated that EPIT induces Foxp3⁺ Tregs that persist long after treatment cessation. Depletion of Tregs during EPIT abrogated its protective effects, while adoptive transfer of Tregs from EPIT-treated mice conferred protection against eosinophilic inflammation upon peanut challenge. These findings highlight the critical role of Tregs in mediating long-term tolerance induced by EPIT.
EPIT induces durable Foxp3⁺ Tregs that are essential for long-term protection against eosinophilic disorders in peanut-sensitized mice.
BALB/c mice sensitized to peanut proteins and treated with EPIT using Viaskin® patches. Tregs were depleted using anti-CD25 antibodies, and adoptive transfer experiments were conducted to assess Treg functionality.
Food allergy, Immunotherapy, Regulatory T cells, Eosinophilic disorders, Peanut allergy
BALB/c mouse model, Epicutaneous immunotherapy, Treg depletion, Adoptive Treg transfer
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
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