Acsl4 conditional Knockout mouse

Target

Gene symbol :

Acsl4

NCBI gene ID :

50790

Gene full name :

Acyl-CoA synthetase long-chain family member 4

Synonym :

ACS4, Facl4, Lacs4, 9430020A05Rik

Protein function

Protein name :

Long-chain fatty acid-CoA ligase 4

Activates long-chain fatty acids to acyl-CoA and regulates membrane lipid composition and ferroptosis-related lipid pathways

Expected phenotype

Altered lipid composition with neuronal and developmental defects and context-dependent ferroptosis sensitivity

Human disease relevance

X-linked intellectual disability and involvement in cancer and ferroptosis biology

Model applications

Model for lipid metabolism and ferroptosis

Keywords:

Fatty acid metabolism, Lipid remodeling, PUFA, Ferroptosis

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Acsl4

conditional Knockout mouse

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