Aicda conditional Knockout mouse

Target

Gene symbol :

Aicda

NCBI gene ID :

11628

Gene full name :

Activation induced cytidine deaminase

Synonym :

AID

Protein function

Protein name :

Activation-induced cytidine deaminase

Catalyzes cytidine deamination during somatic hypermutation and class switch recombination in B cells

Expected phenotype

Knockout mice lack class switch recombination and somatic hypermutation, resulting in impaired antibody diversification

Human disease relevance

Hyper-IgM syndrome, B-cell lymphomas, autoimmunity

Model applications

Immunology models, antibody diversification studies

Keywords:

somatic hypermutation, class switch recombination, B cells

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Aicda

conditional Knockout mouse

Get in touch about

Let us know how we can help

Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

Collaborative approach

Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

Robust validation data on catalog models

Generated with biopharma partners and in-house

Innovative technologies

and guaranteed freedom to operate

Easy access to models

Models with certified health status from professional breeders in US and Europe