Aicda conditional Knockout mouse

Target

Gene symbol :

Aicda

NCBI gene ID :

11628

Gene full name :

Activation induced cytidine deaminase

Synonym :

AID

Protein function

Protein name :

Activation-induced cytidine deaminase

Catalyzes cytidine deamination during somatic hypermutation and class switch recombination in B cells

Expected phenotype

Knockout mice lack class switch recombination and somatic hypermutation, resulting in impaired antibody diversification

Human disease relevance

Hyper-IgM syndrome, B-cell lymphomas, autoimmunity

Model applications

Immunology models, antibody diversification studies

Keywords:

somatic hypermutation, class switch recombination, B cells

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Aicda

conditional Knockout mouse

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