Atxn2 conditional Knockout mouse

Target

Gene symbol :

Atxn2

NCBI gene ID :

20239

Gene full name :

Ataxin 2

Synonym :

Ataxin-2, Spinocerebellar ataxia 2

Protein function

Protein name :

Ataxin-2

RNA-binding protein regulating translation and stress granules; modulates TDP-43 toxicity.

Expected phenotype

Neurodegeneration, motor defects

Human disease relevance

Implicated in spinocerebellar ataxia 2 (SCA2), ALS

Model applications

Neurodegeneration, RNA metabolism, motor neuron disease

Keywords:

SCA2, TDP-43, RNA granules, ALS

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Atxn2

conditional Knockout mouse

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