Bace2 conditional Knockout mouse

Target

Gene symbol :

Bace2

NCBI gene ID :

56175

Gene full name :

Beta-site APP cleaving enzyme 2

Synonym :

Asp2, Beta-secretase 2

Protein function

Protein name :

Beta-secretase 2

Aspartyl protease that cleaves APP and other substrates, distinct from BACE1 in expression and function

Expected phenotype

Knockout mice show altered pancreatic beta-cell function and metabolic phenotypes

Human disease relevance

Alzheimer disease, diabetes

Model applications

Neurodegeneration and metabolic disease models

Keywords:

APP processing, aspartyl protease

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Bace2

conditional Knockout mouse

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