Btk conditional Knockout mouse

Target

Gene symbol :

Btk

NCBI gene ID :

12229

Gene full name :

Bruton tyrosine kinase

Synonym :

Xid, Bruton

Protein function

Protein name :

BTK

Non-receptor tyrosine kinase critical for B-cell development and receptor signaling.

Expected phenotype

Blocked B-cell maturation, immunodeficiency

Human disease relevance

Responsible for X-linked agammaglobulinemia (XLA)

Model applications

Immunodeficiency models, B-cell receptor signaling

Keywords:

B-cell, XLA, Immunodeficiency, BTK inhibitors

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Btk

conditional Knockout mouse

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Models with certified health status from professional breeders in US and Europe