Cbl conditional Knockout mouse

Target

Gene symbol :

Cbl

NCBI gene ID :

12402

Gene full name :

Cbl proto-oncogene

Synonym :

c-Cbl, Cbl1

Protein function

Protein name :

CBL E3 ubiquitin ligase

E3 ubiquitin ligase regulating receptor tyrosine kinase signaling, controls protein turnover and signal attenuation

Expected phenotype

Immune dysregulation, altered lymphocyte signaling, developmental defects in loss-of-function models

Human disease relevance

Leukemia, immune disorders, cancer

Model applications

Signal transduction, immune regulation models

Keywords:

ubiquitination, tyrosine kinase signaling

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Cbl

conditional Knockout mouse

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