Target

Gene symbol :  
Cdk8
NCBI gene ID :  
264064
Gene full name :  
Cyclin dependent kinase 8
Synonym :  
Srb10, CDK8L

Protein function

Protein name :  
Cyclin-dependent kinase 8
Transcription-associated kinase within the Mediator complex, regulates RNA polymerase II activity

Expected phenotype

Altered transcriptional regulation, developmental and metabolic defects in functional models

Human disease relevance

Cancer, developmental disorders

Model applications

Transcription regulation, oncogenic signaling models

Keywords:

Mediator complex, transcription control, kinase

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
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Cdk8

conditional Knockout mouse

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