Cgas conditional Knockout mouse

Target

Gene symbol :

Cgas

NCBI gene ID :

214763

Gene full name :

Cyclic GMP-AMP synthase

Synonym :

Mb21d1, cGAS

Protein function

Protein name :

cGAS enzyme

Cytosolic DNA sensor that synthesizes cGAMP to activate innate immune response via STING pathway

Expected phenotype

Impaired antiviral response and innate immunity defects

Human disease relevance

Autoimmune disease, viral susceptibility

Model applications

Innate immunity and inflammation models

Keywords:

DNA sensing, interferon response

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Cgas

conditional Knockout mouse

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