Chrna1 conditional Knockout mouse

Target

Gene symbol :

Chrna1

NCBI gene ID :

11435

Gene full name :

Cholinergic receptor nicotinic alpha 1 subunit

Synonym :

AChRalpha1, Achra1

Protein function

Protein name :

Nicotinic acetylcholine receptor alpha-1

Structural subunit of the neuromuscular junction acetylcholine receptor, mediates synaptic transmission

Expected phenotype

Severe neuromuscular transmission defects, perinatal lethality in knockout mice

Human disease relevance

Congenital myasthenic syndromes

Model applications

Neuromuscular and synapse biology models

Keywords:

acetylcholine receptor, neuromuscular junction

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Chrna1

conditional Knockout mouse

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