Derl2 conditional Knockout mouse

Target

Gene symbol :

Derl2

NCBI gene ID :

116891

Gene full name :

Derlin 2

Synonym :

Derlin2, Der2

Protein function

Protein name :

Derlin-2 protein

Component of the ER-associated degradation pathway, mediates retrotranslocation of misfolded proteins from ER to cytosol

Expected phenotype

Disruption affects ER stress tolerance and protein quality control

Human disease relevance

Neurodegenerative diseases, protein misfolding disorders

Model applications

ER stress and proteostasis models

Keywords:

ERAD, unfolded protein response

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Derl2

conditional Knockout mouse

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