Eif2b5 conditional Knockout mouse

Target

Gene symbol :

Eif2b5

NCBI gene ID :

224045

Gene full name :

Eukaryotic translation initiation factor 2B subunit 5 epsilon

Synonym :

Protein function

Protein name :

eIF2B epsilon subunit

Catalytic subunit of eIF2B controlling translation initiation and the integrated stress response

Expected phenotype

White matter abnormalities and neurodegeneration in disease models

Human disease relevance

Vanishing white matter leukodystrophy

Model applications

Model for translation control and neurodegeneration

Keywords:

Translation initiation, eIF2B, Stress response, Leukodystrophy

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Eif2b5

conditional Knockout mouse

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