Hcn4 conditional Knockout mouse

Target

Gene symbol :

Hcn4

NCBI gene ID :

330953

Gene full name :

Hyperpolarization activated cyclic nucleotide gated potassium channel 4

Synonym :

BCNG-4, Pacemaker channel 4

Protein function

Protein name :

HCN4 channel

Ion channel generating pacemaker currents in heart and neurons, controls rhythmic electrical activity

Expected phenotype

Severe cardiac conduction defects, embryonic or perinatal lethality in null mutants

Human disease relevance

Cardiac arrhythmias, sinus node dysfunction

Model applications

Cardiac electrophysiology models

Keywords:

pacemaker current, cardiac rhythm

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Hcn4

conditional Knockout mouse

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