Il2ra conditional Knockout mouse

Target

Gene symbol :

Il2ra

NCBI gene ID :

16184

Gene full name :

Interleukin 2 receptor alpha chain

Synonym :

Cd25

Protein function

Protein name :

IL-2 receptor alpha chain

High-affinity IL-2 receptor subunit essential for T cell activation and regulatory T cell function

Expected phenotype

Severe immune dysregulation, autoimmunity, lymphoproliferation when disrupted

Human disease relevance

Autoimmune diseases, immunodeficiency

Model applications

T cell biology, immune tolerance models

Keywords:

IL-2 signaling, regulatory T cells

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Il2ra

conditional Knockout mouse

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