Mlh1 conditional Knockout mouse

Target

Gene symbol :

Mlh1

NCBI gene ID :

17350

Gene full name :

MutL homolog 1

Synonym :

MutL homolog 1, HNPCC2

Protein function

Protein name :

DNA mismatch repair protein MLH1

Core component of the DNA mismatch repair pathway, maintains genomic stability

Expected phenotype

Increased mutation rates, tumor susceptibility, infertility in knockout mice

Human disease relevance

Lynch syndrome, colorectal cancer

Model applications

Cancer and DNA repair models

Keywords:

mismatch repair, genome stability

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Mlh1

conditional Knockout mouse

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