Mthfr conditional Knockout mouse

Target

Gene symbol :

Mthfr

NCBI gene ID :

17769

Gene full name :

Methylenetetrahydrofolate reductase

Synonym :

Methylenetetrahydrofolate reductase

Protein function

Protein name :

MTHFR enzyme

Catalyzes conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, essential for folate metabolism

Expected phenotype

Elevated homocysteine levels, vascular and developmental abnormalities

Human disease relevance

Cardiovascular disease, neural tube defects

Model applications

Folate metabolism and developmental models

Keywords:

folate metabolism, methylation

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Mthfr

conditional Knockout mouse

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