Nae1 conditional Knockout mouse

Target

Gene symbol :

Nae1

NCBI gene ID :

234664

Gene full name :

NEDD8 activating enzyme E1 subunit 1

Synonym :

APPBP1

Protein function

Protein name :

NEDD8-activating enzyme regulatory subunit

Component of the NEDD8 activating enzyme complex, required for protein neddylation and ubiquitin-like modification

Expected phenotype

Embryonic lethality, impaired protein regulation

Human disease relevance

Cancer, proteostasis disorders

Model applications

Ubiquitin-like modification and proteostasis models

Keywords:

neddylation, ubiquitin pathway

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Nae1

conditional Knockout mouse

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