Parl conditional Knockout mouse

Target

Gene symbol :

Parl

NCBI gene ID :

381038

Gene full name :

Presenilin associated rhomboid-like

Synonym :

PSARL

Protein function

Protein name :

Rhomboid-related intramembrane serine protease PARL

Mitochondrial protease involved in apoptosis and mitochondrial dynamics

Expected phenotype

KO mice show altered mitochondrial morphology and muscle atrophy

Human disease relevance

Implicated in Parkinson’s disease and mitochondrial dysfunction

Model applications

Studied in neurodegeneration and mitochondrial quality control

Keywords:

Mitochondria, Apoptosis, Parkinson's, Protease

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Parl

conditional Knockout mouse

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