Parp1 conditional Knockout mouse

Target

Gene symbol :

Parp1

NCBI gene ID :

11545

Gene full name :

Poly ADP-ribose polymerase 1

Synonym :

ADPRT1, ART1

Protein function

Protein name :

PARP1 enzyme

Catalyzes ADP-ribosylation of target proteins in response to DNA damage, regulates DNA repair and transcription

Expected phenotype

Increased sensitivity to DNA damage, genomic instability

Human disease relevance

Cancer, neurodegeneration

Model applications

DNA repair and cancer therapy models

Keywords:

DNA repair, ADP-ribosylation

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Parp1

conditional Knockout mouse

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