Slc7a11 conditional Knockout mouse

Target

Gene symbol :

Slc7a11

NCBI gene ID :

26570

Gene full name :

Solute carrier family 7 member 11

Synonym :

xCT

Protein function

Protein name :

Cystine/glutamate antiporter

Transports cystine into cells in exchange for glutamate; critical for glutathione synthesis and redox homeostasis

Expected phenotype

Knockout mice show impaired antioxidant defense, increased oxidative stress sensitivity, altered immune and neuronal responses

Human disease relevance

Implicated in cancer (tumor redox balance), neurodegeneration, ferroptosis-related diseases

Model applications

Cancer metabolism models, ferroptosis studies, oxidative stress research

Keywords:

cystine transport, glutathione, ferroptosis, redox balance

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Slc7a11

conditional Knockout mouse

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