Tmc8 conditional Knockout mouse

Target

Gene symbol :

Tmc8

NCBI gene ID :

217356

Gene full name :

Transmembrane channel-like 8

Synonym :

E8, EVER2

Protein function

Protein name :

Transmembrane channel-like protein 8

Regulates zinc homeostasis in keratinocytes; restricts papillomavirus replication

Expected phenotype

Altered skin immune responses; increased susceptibility to papillomavirus-related lesions

Human disease relevance

Epidermodysplasia verruciformis (HPV susceptibility)

Model applications

Skin immunity, viral restriction, host–virus interaction models

Keywords:

HPV, zinc regulation, keratinocytes, skin immunity

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Tmc8

conditional Knockout mouse

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