Tnfrsf9 conditional Knockout mouse

Target

Gene symbol :

Tnfrsf9

NCBI gene ID :

21942

Gene full name :

Tumor necrosis factor receptor superfamily member 9

Synonym :

4-1BB, CD137

Protein function

Protein name :

CD137 antigen

Costimulatory receptor on activated T cells; enhances T-cell proliferation and survival

Expected phenotype

Impaired T-cell activation and antitumor immunity when disrupted

Human disease relevance

Cancer immunotherapy target; immune dysregulation

Model applications

Immuno-oncology models, T-cell activation studies

Keywords:

costimulation, T cells, immunotherapy

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Tnfrsf9

conditional Knockout mouse

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Models with certified health status from professional breeders in US and Europe