Xbp1 conditional Knockout mouse

Target

Gene symbol :

Xbp1

NCBI gene ID :

22433

Gene full name :

X-box binding protein 1

Synonym :

Xbp

Protein function

Protein name :

X-box-binding protein 1

Transcription factor activated by IRE1-mediated splicing during the unfolded protein response, regulates ER stress adaptation, plasma cell differentiation, lipid metabolism

Expected phenotype

Conditional deletion shows defective plasma cell development, impaired antibody secretion, altered secretory cell function

Human disease relevance

Involved in cancer, metabolic disorders, inflammatory diseases, neurodegeneration

Model applications

Immunology models, ER stress and UPR studies, plasma cell biology

Keywords:

unfolded protein response, ER stress, plasma cells, transcription factor

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Xbp1

conditional Knockout mouse

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