Customized Transgenic Mouse & Knockout Mouse Models

The design and physiological relevancy of a customized transgenic mouse and Knockout mouse model to be used for in vivo studies is key for the success of these projects.

Producing such a model usually means a very steep financial investment as well as a large time consumption. genOway helps secure your investment by providing you with the most reliable genome engineering mouse services currently on the market.

Regardless of the desired model genOway is asked to develop, we provide outstanding consulting services including, but not limited to:

  • A thorough assessment of the risks and benefits of each project,
  • An analysis of the potential trouble spots during development, and
  • An accurate timeline of the entire development process.

Custom Knockout Mouse Models

Conventional Knockout Mice (constitutive)
Permanently inactivates a target gene in every cell of the organism.

Tissue-specific Knockout Mice (conditional)
Inactivates gene expression in a specific target tissue.

Inducible Knockout Mice
Inactivates gene expression in a time-controlled manner.

Safe Knockout
Enables the creation of both: a constitutive and a conditional knockout model of the same target gene.

Custom Knockin or Transgenic Mouse Models

Humanized mice
Replaces a mouse gene with its human counterpart.

Point mutation mice
Introduces a specific point mutation at a specific nucleotide position within the gene of interest.

Inducible point mutation mice
Introduces a point mutation in a time-controlled manner.

Reporter mice
Introduces a reporter gene into the locus of a target gene in order to monitor the expression of that gene at the transcriptional or translational level. May also be used to monitor protein trafficking.

Rosa26 and Hprt targeted transgenesis
Introduces a safe and targeted insertion of a transgene into the Rosa26 or Hprt locus.