Conditional Knockout Rat Models
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A conditional Knockout rat defines an animal model in which a gene of interest can be:
Inactivated in specific cell types in a certain tissue; other cell types and tissues exhibit an unmodified, functional gene expression
→ Tissue-specific Knockout rat model
Temporally suppressed at a given time-point in embryonic, post-natal or adult animals
→ Inducible Knockout rat model
Conditional Knockout rat models can bypass the limits that are usually observed with constitutive Knockout rat models (e.g., embryonic lethality, compensatory mechanisms or complex phenotype). The phenotype can also be more reliably associated with inactivation of the target gene.
How does it work?
The most commonly used technique is the Cre-loxP system (see also site-specific recombination). The Cre recombinase recognizes the loci of recombination loxP that causes a deletion of the gene between the two loxP sites.
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