Applications of the genO‑hTNF-α mouse model

Useful applications for researchers working on different biomedical fields, such as inflammation and autoimmunity:

  • Assess the efficacy of TNF-α-targeting therapeutics
  • Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential

Features

  • Physiological regulation and expression pattern of TNF-α
  • Conservation of the TNF-α downstream signaling
  • No expression of murine TNF-α
  • Fully functional mouse immune system

Clients

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Model Delivery & Logistics

  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders in the US and Europe

Validation data

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genO‑hTNF-α

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Humanized genO‑hTNF-α mouse model

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Easy access to models

Models with certified health status from professional breeders in US and Europe