Applications of the genO‑hcGAS mouse model

Broad range of applications in the fields of immuno-oncology, autoimmunity and infectious diseases:

  • Assess the efficacy of cGAS-targeting compounds
  • Gain insights into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefits

Features

  • Physiological regulation and expression of human cGAS
  • Fully functional mouse immune system
  • Lack of expression of the murine target gene

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Model Delivery & Logistics

  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders in the US and Europe

Validation data

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genO‑hcGAS

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STING
cGAS-STING pathway

genO‑hSTING

The genO‑hSTING mouse enables the in vivo assessment of agents and therapies targeting the human STING in fully immunocompetent mice.

Preclinical humanized genO‑hcGAS mouse model

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Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

Collaborative approach

Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

Robust validation data on catalog models

Generated with biopharma partners and in-house

Innovative technologies

and guaranteed freedom to operate

Easy access to models

Models with certified health status from professional breeders in US and Europe