Applications of the hPD‑1 mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology, immuno-inflammation and autoimmunity:
- Assess the efficacy of PD-1-targeting compounds
- Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
- Evaluate PD-1 agonists for the treatment of autoimmune and inflammatory conditions
- Gain insights into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefits
Features
- Physiological regulation and expression of a humanized PD-1
- Lack of expression of the murine target gene
- Fully functional mouse immune system
- Available on different genetic backgrounds C57BL/6 & BALB/c
Validation
hPD‑1 expression pattern and modulation upon activation recapitulates mPD‑1
hPD-1 and mPD-1 expression on αCD3/αCD28-activated splenocytes on (A) Tregs, conventional CD4+ at day 2 of culture and (B) on CD8+ T cells at the indicated time points.
In vivo anti-tumor activity is observed in response to anti-human PD-1 treatment in genO‑hPD‑1 mice
Survival of mice of indicated genotype implanted intracranially with GL261 murine glioma cells and treated with αhPD-1 or αmPD-1 (Mantel-Cox test: ***p<0.001).
Preclinical humanized genO-hPD-1 mouse model
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