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PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451
Biomaterials
Oct 2024
Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition
Geroscience
Jul 2024
Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia
Invest Ophthalmol Vis Sci
Jun 2024
Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution
JCI Insight
May 2024
Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression
Mol Cancer Ther
May 2024
Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy
Nat Neurosci
May 2024
Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells
J Am Soc Nephrol
Apr 2024
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia
Neurobiol Dis
Mar 2024
The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration
Nat Commun
Mar 2024
The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function
Cell Death Dis
Jan 2024
Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes
Life Sci Alliance
Jan 2023
Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating Aquaporin-4 after traumatic brain injury in mice
Heliyon
Jan 2023
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis
Nat Commun
Jan 2023
NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes
iScience
Jan 2023
PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia
Autophagy
Jan 2023
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling
Nat Commun
Jan 2023
Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease
Glia
Jan 2023
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth
Nat Metab
Jan 2022
Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection
Sci Rep
Jan 2022
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD
Acta Neuropathol
Jan 2022
Apelin controls emotional behavior in age- and metabolic state-dependent manner
Psychoneuroendocrinology
Jan 2022
Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis
Prog Neurobiol
Jan 2022
Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer
Breast Cancer Res
Jan 2022
Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion
Nat Commun
Jan 2022
Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH
Biochim Biophys Acta Mol Basis Dis
Jan 2022
PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis
Cell Metab
Jan 2022
Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression
PLoS One
Jan 2022
R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System
Int J Mol Sci
Jan 2022
ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways
Biol Trace Elem Res
Jan 2022
Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain
Brain
Jan 2022
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction
Cell Rep
Jan 2022
Monocarboxylate transporter 1 deficiency impacts CD8 + T lymphocytes proliferation and recruitment to adipose tissue during obesity
iScience
Jan 2022
ACT1 is required for murine IL-23-induced psoriasiform inflammation potentially independent of E3 ligase activity
J Invest Dermatol
Jan 2021
Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall
Cell Rep
Jan 2021
Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract
Cardiovasc Res
Jan 2021
CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
Nat Commun
Jan 2021
Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32
Cell Mol Immunol
Jan 2021
Endoplasmic reticulum maintains ion homeostasis required for plasma membrane repair
J Biol Chem
Jan 2021
Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease
Matrix Biol
Jan 2021
Fibroblast-derived IL-33 is dispensable for lymph node homeostasis but critical for CD8 T cell responses to acute and chronic viral infection
Eur J Immunol
Jan 2021
Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration
JCI Insight
Jan 2021
Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage
Proc Natl Acad Sci U S A
Jan 2021
Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist
Proc Natl Acad Sci U S A
Jan 2021
Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis
PLoS One
Jan 2021
Knocking down Israa, the Zmiz1 intron-nested gene, unveils interrelated T cell activation functions in mouse
Biochem Biophys Rep
Jan 2021
Long Acellular Nerve Allografts Cap Transected Nerve to Arrest Axon Regeneration and Alter Upstream Gene Expression in a Rat Neuroma Model
Plast Reconstr Surg
Jan 2021
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
Cell
Jan 2021
The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice
Proc Natl Acad Sci U S A
Jan 2021
Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model
Glia
Jan 2021
ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity
Sci Transl Med
Jan 2021
Cathepsin S Evokes PAR (2)-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models
Cancers (Basel)
Jan 2021
Influenza A virus infection-induced macroautophagy facilitates MHC class II-restricted endogenous presentation of an immunodominant viral epitope
FEBS J
Jan 2021
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2
J Neurosci
Jan 2021
Novel compounds with dual S1P receptor agonist and histamine H 3 receptor antagonist activities act protective in a mouse model of multiple sclerosis
Neuropharmacology
Jan 2021
Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
Commun Biol
Jan 2021
Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective Following Ischemic Brain Injury
J Neurosci
Jan 2020
Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke
Nat Neurosci
Jan 2020
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res
Jan 2020
Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells
Immunity
Jan 2020
Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease
Cell Death Dis
Jan 2020
Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1+/− Mice
Int J Mol Sci
Jan 2020
Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils
Sci Signal
Jan 2020
HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis
Cell Rep
Jan 2020
Intracellular Role for the Matrix-Modifying Enzyme Lox in Regulating Transcription Factor Subcellular Localization and Activity in Muscle Regeneration
Dev Cell
Jan 2020
Migration-induced cell shattering due to DOCK8 deficiency causes a type 2-biased helper T cell response
Nat Immunol
Jan 2020
Nolz1 expression is required in dopaminergic axon guidance and striatal innervation
Nat Commun
Jan 2020
The Non-Receptor Tyrosine Kinase Pyk2 Modulates Acute Locomotor Effects of Cocaine in D1 Receptor-Expressing Neurons of the Nucleus Accumbens
Sci Rep
Jan 2020
αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus
Mucosal Immunol
Jan 2020
Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury
J Am Heart Assoc
Jan 2020
FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake
Cell Metab
Jan 2020
Assessment of fear and anxiety associated behaviors, physiology and neural circuits in rats with reduced serotonin transporter (SERT) levels
Transl Psychiatry
Jan 2019
Comparison of Myelin-Associated Glycoprotein With Vincristine for Facial Nerve Inhibition After Bilateral Axotomy in a Transgenic Thy1-Gfp Rat Model
JAMA Facial Plast Surg
Jan 2019
Constitutive serotonin transporter reduction resembles maternal separation with regard to stress-related gene expression
ACS Chem Neurosci
Jan 2019
Helicase-like transcription factor (Hltf) gene-deletion promotes oxidative phosphorylation (OXPHOS) in colorectal tumors of AOM/DSS-treated mice
PLoS One
Jan 2019
Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations
Cell Metab
Jan 2019
Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes.
Nitric Oxide
Jan 2019
Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle.
Cell Rep
Jan 2019
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