Catalog of immuno-oncology mouse models

Humanized immune checkpoints

• Fully immunocompetent models featuring humanized immune checkpoints and functional immune system (including interaction with stroma /microenvironment)
• Biologics’ assessment (including bispecific)
• Broad spectrum of humanized targets
• Easy detection of Treg (e.g., GITR/Foxp3-mRFP)
• Undisclosed targets under validation
• Intercrosses available upon request

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Immunodeficient model: BRGSF

• The most immunodeficient mouse model: defects in the myeloid and lymphoid compartments (Rag2^-/-, IL‑2Rγ^-/-, Flk2^-/-)
• Radio-resistant (absence of the SCID mutation on a BALB/c background)
• Highly permissive to patient-derived xenografts (PDXs) and cell line engraftment (SIRPαNOD)

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Models for PK/PD studies: HSA/hFcRn

• Double humanized model displaying physiological relevance due to the autologous HSA/hFcRn interaction
• Preclinical studies of albumin-based drugs and drugs influenced by reversible binding to HSA
• Development of albumin-based or Fc-fused drugs
• Available onto immunodeficient genetic background (Rag1^-/-)

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