Applications

  • Accurate and predictive PK/PD studies of albumin- and FcRn-binding compounds
  • Development of conventional drugs and biologics with enhanced half-lifethrough interaction with HSA and hFcRn
  • Assessment of a variety of compounds, including albumin variants, small molecules, antibody-like biologics and antibodies, including T-cell engager

HSA/hFcRn model features

  • Physiological HSA and hFcRn expression profile and regulation in a mouse system, as they are both controlled by their respective endogenous mouse promoters
  • Physiological expression level of human albumin in a mouse system (within the normal range of 1.5-6 g/dL)
  • Normal blood chemistry compared to a wild-type mouse
  • Murine SA and FcRn expression is abolished

Validation

Related ressources et publications

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