Several partners have co-validated the genO-hSA/hFcRn mouse model

Key publications & posters


What sets the genO-hSA/hFcRn mouse model apart?

  • Physiological expression pattern and levels of expression of both hSA and hFcRn
  • Serum albumin and FcRn are humanized to optimize drug binding, as murine albumin has higher affinity for hFcRn than human albumin


Create a customized model for PK and efficacy evaluation of your antibody

Thanks to 25 years of proven track record in developing custom-made models, genOway offers an in-depth analysis of projects to design a model fully adapted to your research, with strategic selection of the gene engineering technology.

Examples of models created with genO-hSA/hFcRn background

In order to expand the range of applications of our genO-hSA/hFcRn mouse, this model has been intercrossed with several other models:

  • genO-hFcγR/hFcRn to improve PK/PD assessment of Fc-dependent antibodies
  • genO-hTFRC/hSA/hFcRn to improve assessment of compounds crossing the blood-brain barrier
  • genO-hSA/hFcRn/hIgG1 for an increased tolerance to human hIgG1

Create a custom-made model for PK Profiling with genO-hSA/hFcRn

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Scientific excellence

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Featured in 600+ scientific articles

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Collaboration with 17 Top Pharmas,
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Models with certified health status from professional breeders in US and Europe