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Applications of the genO‑hFcγR/hFcRn mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology, infectious diseases and autoimmunity:
- Assess pharmacokinetics and pharmacodynamics (PK/PD) features, including biodistribution and binding affinity
- Screen FcR-binding therapeutics based on extended half-life
- Assess the efficacy of optimized therapeutics such as Fc-engineered antibodies, constructs fused to hSA, FcRn-binding proteins or small molecules
Features
- Physiological expression and distribution of human FcγR and human FcRn
- Higher physiological affinity of human serum albumin to human FcRn
- Functional receptors enabling assessment of Fc-mediated effector functions
- No expression of murine FcγR nor murine FcRn
- Fully immunocompetent model
Clients
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