A4galt conditional Knockout mouse

Target

Gene symbol :

A4galt

NCBI gene ID :

239559

Gene full name :

Alpha 1,4-galactosyltransferase

Synonym :

Gb3 synthase, Glt6

Protein function

Protein name :

Lactosylceramide 4-alpha-galactosyltransferase

Synthesizes globotriaosylceramide (Gb3), key glycosphingolipid

Expected phenotype

KO mice lack Gb3, resistant to Shiga toxin

Human disease relevance

Involved in Fabry disease and Shiga toxin susceptibility

Model applications

Used in glycosphingolipid and infectious disease models

Keywords:

Glycosylation, Gb3, Shiga toxin, Sphingolipid

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

A4galt

conditional Knockout mouse

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