Mechanism & Mode of action

Our selection of catalog models includes different types of models useful for MoA assessment.​

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Target-specific humanized models​

A wide range of target-specific humanized strains is available and ready for purchase. These models are immunocompetent, and display a physiological expression of the human target. Some of the models present in our catalog include:

• Several humanized immune checkpoint models, such as the genO-hPD-1, genO-hGITR, and genO-hVISTA models, among many others. These models have been successfully used to understand the mode of action of different drugs, or even for advancing our knowledge in fundamental biology. You can read here some interesting papers from Abbvie and BMS to see how our models have contributed to different scientific advances.
• Humanized CD3 models are also available, not only to assess the efficacy of new T-cell engagers but also how these drugs work. The genO‑panhCD3 and genO‑hCD3ε models have been validated by our clients, such as AstraZeneca (Gaspar et al., 2025) and Pfizer (Abayasiriwardana et al., 2025), respectively, and helped them understand the mechanism through which their TCEs induced tumor growth inhibition.
• Our humanized FcγR model can also be a powerful tool for understanding the contribution of Fc receptors to the response elicited by a therapeutic antibody. This was recently demonstrated by Pilati et al., in the context of malaria infection.

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Cell lines

If you are aiming to understand how your drug works within the context of a tumor, our humanized mouse models can be used for syngeneic studies, for which there is available a complementary catalog of cell lines.

• A variety of cell lines are available, such as colon carcinoma cells lines (MC38 and CT26, for C57BL/6 and BALB/c mice, respectively) or a lymphoma cell line (EL4).
• These cell lines are engineered to express human proteins such as CD19 or CD20 (in the EL4 background), or humanized immune checkpoints (in MC38 and CT26 backgrounds).
• We also provide a range of reporter and Knockout cell lines, which can be used as a control for your efficacy studies and target validation.

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Humanized immune system (HIS) models

As part of our catalog, we also provide humanized mouse models with a human immune system (HIS), such as the genO-BRGSF-HIS and genO-BRGSF-A2-HIS models. Given their extended lifespan, functional human myeloid and lymphoid compartments, and permissiveness to PDX and CDX engraftments, these models are ideal for the translational understanding of the MoA or MOA of a therapeutic in the context of human tumors, such as understanding how it might polarize cells within the tumor microenvironment, or lead to the recruitment of cytotoxic cells (AACR 2025 poster).

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Immunodeficient models 

In our vast portfolio, you can also find immunodeficient rodents. If you are trying to understand the contribution of the immune system in the effect of your compound, then our immunodeficient models can be useful to you. They also support PDX and CDX engraftment if you want to perform your analysis in the context of a tumor, as well as allow longer experimental timeframes due to their extended longevity.

If you are looking for a unique model that is not part of our portfolio, we can also make a customized model for you. Our scientists will consider all of your needs and create the best model to fit your research. You can easily book a discussion session and we will guide you through the process.