Target

Gene symbol :  
Bmpr2
NCBI gene ID :  
12168
Gene full name :  
Bone morphogenetic protein receptor type II
Synonym :  
BMPRII, Alk3b

Protein function

Protein name :  
BMPR2
Serine/threonine kinase receptor in BMP signaling; regulates vascular and bone development.

Expected phenotype

Vascular remodeling defects, altered bone growth

Human disease relevance

Associated with pulmonary arterial hypertension (PAH)

Model applications

Vascular disease models, bone signaling

Keywords:

BMP signaling, PAH, TGF-beta pathway

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Bmpr2

conditional Knockout mouse

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