Card9 conditional Knockout mouse

Target

Gene symbol :

Card9

NCBI gene ID :

332579

Gene full name :

Caspase recruitment domain family, member 9

Synonym :

Caspase recruitment domain-containing protein 9

Protein function

Protein name :

CARD9

Adapter protein in innate immune signaling downstream of pattern recognition receptors

Expected phenotype

KO mice show impaired antifungal immunity and defective cytokine responses

Human disease relevance

Mutations cause susceptibility to fungal infections in humans

Model applications

Model for innate immunity, mycosis, and inflammasome signaling

Keywords:

Innate immunity, NF-κB, Fungal infections, Inflammation

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Card9

conditional Knockout mouse

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