Cyp2r1 conditional Knockout mouse

Target

Gene symbol :

Cyp2r1

NCBI gene ID :

244209

Gene full name :

Cytochrome P450, family 2, subfamily R, polypeptide 1

Synonym :

Vitamin D 25-hydroxylase

Protein function

Protein name :

Vitamin D 25-hydroxylase

Catalyzes 25-hydroxylation of vitamin D to active form

Expected phenotype

KO leads to reduced 25(OH)D and vitamin D deficiency

Human disease relevance

Mutations cause vitamin D–dependent rickets type 1B

Model applications

Used in bone metabolism and vitamin D pathway research

Keywords:

Vitamin D metabolism, Cytochrome P450, Rickets, Bone biology

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Cyp2r1

conditional Knockout mouse

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