Depdc5 conditional Knockout mouse

Target

Gene symbol :

Depdc5

NCBI gene ID :

277854

Gene full name :

DEP domain containing 5

Synonym :

DEPDC5

Protein function

Protein name :

DEP domain-containing protein 5

Component of GATOR1 complex; negative regulator of mTORC1 pathway

Expected phenotype

KO causes embryonic lethality; heterozygous KO may show seizure susceptibility

Human disease relevance

Mutations linked to familial focal epilepsy and cortical malformations

Model applications

Model for epilepsy, mTOR regulation, neurodevelopment

Keywords:

mTOR, Epilepsy, GATOR1, Neurodevelopment, Seizure model

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Depdc5

conditional Knockout mouse

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