Target

Gene symbol :  
Gclc
NCBI gene ID :  
14629
Gene full name :  
Glutamate-cysteine ligase, catalytic subunit
Synonym :  
GLCL, GSH1

Protein function

Protein name :  
GCLC
Catalytic subunit of the enzyme initiating glutathione synthesis; protects from oxidative stress.

Expected phenotype

Reduced GSH, oxidative damage

Human disease relevance

Involved in liver disease, neurodegeneration

Model applications

Glutathione metabolism, antioxidant defense

Keywords:

GSH synthesis, Oxidative stress, Detox

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Gclc

conditional Knockout mouse

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