Mthfd1l conditional Knockout mouse

Target

Gene symbol :

Mthfd1l

NCBI gene ID :

270685

Gene full name :

Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

Synonym :

MTHFD1-like

Protein function

Protein name :

Mitochondrial MTHFD1-like enzyme

Key enzyme in mitochondrial folate cycle and one-carbon metabolism

Expected phenotype

KO is embryonic lethal due to folate pathway defects

Human disease relevance

Associated with neural tube defects and mitochondrial disorders

Model applications

Model for folate metabolism and developmental biology

Keywords:

One-carbon metabolism, Folate cycle, Mitochondrial, Development

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Mthfd1l

conditional Knockout mouse

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