Pcsk9 conditional Knockout mouse

Target

Gene symbol :

Pcsk9

NCBI gene ID :

100102

Gene full name :

Proprotein convertase subtilisin/kexin type 9

Synonym :

NARC-1

Protein function

Protein name :

Proprotein convertase subtilisin/kexin type 9

Regulates cholesterol homeostasis by promoting LDLR degradation

Expected phenotype

Knockouts show reduced plasma cholesterol levels

Human disease relevance

Mutations linked to familial hypercholesterolemia

Model applications

Widely used in cardiovascular and lipid metabolism models

Keywords:

Cholesterol, LDL receptor, Cardiovascular, PCSK family

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Pcsk9

conditional Knockout mouse

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