Setdb1 conditional Knockout mouse

Target

Gene symbol :

Setdb1

NCBI gene ID :

84505

Gene full name :

SET domain, bifurcated 1

Synonym :

ESET, KMT1E, mKIAA0067

Protein function

Protein name :

Histone‑lysine methyltransferase SETDB1

Catalyzes H3K9 methylation; represses transposons and regulates chromatin architecture

Expected phenotype

Knockouts cause early embryonic lethality, neural defects; overexpression alters behavior

Human disease relevance

Mutations linked to neurodevelopmental disorders and cancer progression, including AML

Model applications

Used in epigenetics, development, neural maturation, and cancer studies

Keywords:

Histone methylation, Epigenetics, Chromatin, Neurodevelopment, Transposon silencing

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Setdb1

conditional Knockout mouse

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