Trnt1 conditional Knockout mouse

Target

Gene symbol :

Trnt1

NCBI gene ID :

70047

Gene full name :

tRNA nucleotidyl transferase, CCA-adding, 1

Synonym :

Cca1

Protein function

Protein name :

tRNA nucleotidyltransferase 1, mitochondrial

Adds CCA to 3' ends of tRNAs; essential for tRNA maturation and translation

Expected phenotype

Knockouts are embryonic lethal; tRNA maturation defects

Human disease relevance

Mutations cause sideroblastic anemia with B-cell immunodeficiency

Model applications

Used in mitochondrial translation and tRNA processing studies

Keywords:

tRNA processing, Mitochondria, Translation, Anemia

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Trnt1

conditional Knockout mouse

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