Gclc conditional Knockout mouse

Target

Gene symbol :

Gclc

NCBI gene ID :

14629

Gene full name :

Glutamate-cysteine ligase, catalytic subunit

Synonym :

GLCL, GSH1

Protein function

Protein name :

GCLC

Catalytic subunit of the enzyme initiating glutathione synthesis; protects from oxidative stress.

Expected phenotype

Reduced GSH, oxidative damage

Human disease relevance

Involved in liver disease, neurodegeneration

Model applications

Glutathione metabolism, antioxidant defense

Keywords:

GSH synthesis, Oxidative stress, Detox

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
WoldWide delivery by professional breeders

Gclc

conditional Knockout mouse

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