Quick Knockin Mouse Models (Neutral Locus Targeting: Rosa26, Hprt)


Get supplemental information, a quote, and estimated timeframe for generating your Quick Knockin mouse.


A Quick Knockin mouse defines an animal model in which a transgene is inserted in a permissive locus, also known as neutral locus or safe harbor, such as example Rosa26 and Hprt. The transgene can be constitutively or inducibly overexpressed.

Targeting those loci enable a full control of the copy number and avoid transgene silencing or deregulation of neighboring genes.

Quick Knockin Models
  • Fast development
  • Broad range of appplications
1) Technology
  • Versatile (time-/tissue-specific; co-expressions)
  • Robust
2) Design
  • Obtain reliable scientific data
  • Anticipate current and future needs



Learn more and watch the video.

Typical applications for Quick Knockin mouse models

For academic research:
  • Gene function studies by overexpression if Knockout has no or little phenotype
  • Rescue experiment to validate specificity of the Knockout phenotype
  • Protein structure and function studies
  • Expression pattern analysis
  • Expression of specific isoform to decipher its particular function
  • Express human gene that has no mouse orthologue
  • Model of dominant negative or gain-of-function mutation of human disease
For bio-pharmaceutical research & development:
  • Validate drug candidate by expression of mutant form of receptor mimicking its role
  • Validate mutation in target as disease-causing agent
  • Test protective effect on controlled gene expression on disease onset or progression
  • Identification biomarkers in human disease model
  • Get mouse model that cross-reacts with human-specific therapeutic antibody (or similar)

Strengths and limitations of Quick Knockin mouse models

  • Very robust approach due to the wide usage of both, Rosa26 and Hprt, by scientific community
  • Fast development due to ready-to-use vectors
  • Several genetic backgrounds are available (C57Bl/6, BALB/c…)
  • Variety of genetic designs to fit a broad range of applications
  • No physiological regulation of the transgene expression
    →  Limitation can be bypassed by using conventional Knockin approach
  • In most cases only one isoform can be expressed
  • Mutated mouse gene is expressed in presence of the wildtype gene

Case studies and publications on our Quick Knockin mouse models

Case studies

Model recapitulating key features of human tauopathies.

Bondulich MK, et al. Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate. Brain. 2016.

Tauopathies are characterized by progressive cognitive and/or motor dysfunction, together with highly phosphorylated aggregates of the microtubule-associated protein tau in brain and peripheral nerve.

Most existing mouse models of tauopathy overexpress mutant tau at levels that do not occur in human neurodegenerative disease.

Model: New highly disease-relevant mouse model of tauopathy expressing Hprt locus-targeted Tau35, highly phosphorylated C-terminal human tau fragment.

Aim: Evaluate a new model of tauopathy for developing novel treatments for human tauopathies.

Results: Tau35 mice represent a pathophysiologically relevant mouse model in which to test new, potentially disease-modifying therapies.


Figure 1. Tau expression in Tau35 mouse brains

Excessive accumulation of cGMP and subsequent rod photoreceptor death, followed by a mutation-independent, secondary death of cone photoreceptors.

Figure 1a - Tau35 mice

A) RT-PCR confirms Tau35 expression.

B) Sagittal sections show widespread hemagglutinin labeling in Tau35 mouse brain (upper panels, scale bar = 2 mm). Higher magnifications of the hippocampal CA1 region show strongly hemagglutinin-positive pyramidal neurons in Tau35 mice (lower panels, scale bar = 200 mm). Western blots of frontal region and hippocampus/associated cortex (HC) show hemagglutinin protein expression only in Tau35 mice.

Figure 1b - Tau35 mice


Figure 2. Progressive neuromuscular impairment

Figure 2a-d - Tau35 mice

A) Limb clasping is apparent in Tau35 mice from 2 months of age (image shows 8 months), with all Tau35 animals affected by 18 months. Clasping is not observed in wildtype (wt) mice at any age examined.

B) Spine curvature is apparent in Tau35, but not wildtype mice, at 14 months of age. A progressive reduction in the kyphotic index in Tau35 mice after 4 months of age indicates increasing spine curvature.

C) Visible platform (VP) training in the Morris water maze was followed by 4 days of hidden platform training. At 10 months of age, Tau35 mice exhibit longer escape latency on the fourth day of testing compared to wildtype mice.

D) The grip strength of Tau35 mice declines steadily with age.


Figure 3. Phenylbutyrate rescues disease-related changes in Tau35 mice.

Figure 3ab - Tau35 mice

A) Morris water maze (10 months) testing of 4-phenylbutyrate (PBA, dotted lines) and vehicle-treated (solid lines) Tau35 (circles) and wildtype (wt, squares) mice. PBA-treated Tau35 mice show improved learning after 3 days, resulting in decreased escape latency.

B) Grip strength of Tau35 (10 months) is restored by PBA treatment.


Hprt | Rosa26

Adeline Sivignon, Mélissa Chervy, Caroline Chevarin, Elia Ragot, Elisabeth Billard, Jérémy Denizot, Nicolas Barnich.
An adherent-invasive Escherichia coli-colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease.
Dis Model Mech. 2022 Oct 1

Álvaro Sebastián-Serrano, Jesús Merchán-Rubira, Caterina Di Lauro, Carolina Bianchi, Lucía Soria-Tobar, Sonoko Narisawa, José L Millán, Jesús Ávila, Félix Hernández, Miguel Díaz-Hernández.
TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy
Neurobiol Dis. 2022 Apr

Charlotte Douglas, Valdone Maciulyte, Jasmin Zohren, Daniel M Snell, Shantha K Mahadevaiah, Obah A Ojarikre, Peter J I Ellis, James M A Turner
CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
Nat Commun. 2021 Dec 3

Faik Imeri, Bisera Stepanovska Tanturovska, Stephanie Schwalm, Sarbari Saha, Jinyang Zeng-Brouwers, Herrmann Pavenstädt, Josef Pfeilschifter, Liliana Schaefer, Andrea Huwiler.
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Matrix Biol. 2021 Apr

Lukas Huijbregts, Virginie Aiello, Andrea Soggia, Philippe Ravassard, Latif Rachdi, Raphaël Scharfmann, Olivier Albagli.
Culture, differentiation, and transduction of mouse E12.5 pancreatic spheres: an in vitro model for the secondary transition of pancreas development.
Islets. 2021 Mar 4

Zeyuan Zhang, Qingwen Qian, Mark Li, Fan Shao, Wen-Xing Ding, Vitor A Lira, Sophia X Chen, Sara C Sebag, Gökhan S Hotamisligil, Huojun Cao, Ling Yang.
The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB.
Autophagy. 2020 Jul 15

Flavia Amadeu de Oliveira, Sonoko Narisawa, Massimo Bottini, José Luis Millán.
Visualization of Mineral-Targeted Alkaline Phosphatase Binding to Sites of Calcification In Vivo.
J Bone Miner Res. 2020 Apr 28.

Zhou L, Flores J, Noël A, Beauchet O, Sjöström PJ, LeBlanc AC.
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.
Acta Neuropathol Commun. 2019 Dec 16.

Tang S, Liu B, Liu M, Li Z, Liu J, Wang H, Wang J, Oh YT, Shen L, Wang Y.
Ionizing radiation-induced growth in soft agar is associated with miR-21 upregulation in wild-type and DNA double strand break repair deficient cells.
DNA Repair (Amst). 2019 Mar 23.

Carneros D, Santamaría EM, Larequi E, Vélez-Ortiz JM, Reboredo M, Mancheño U, Perugorria MJ, Navas P, Romero-Gómez M, Prieto J, Hervás-Stubbs S, Bustos M.
Cardiotrophin-1 is an anti-inflammatory cytokine and promotes IL-4-induced M2 macrophage polarization.
FASEB J. 2019 Mar 20.

Plucińska K, Crouch B, Yeap JM, Stoppelkamp S, Riedel G, Platt B.
Histological and Behavioral Phenotypes of a Novel Mutated APP Knock-In Mouse.
J Alzheimers Dis. 2018 Aug 7.

Beyer S, Schwalm S, Pfeilschifter J, Huwiler A.
Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis.
Cell Physiol Biochem. 2018 Jul 10.

Eresch J, Stumpf M, Koch A, Vutukuri R, Ferreirós N, Schreiber Y, Schröder K, Devraj K, Popp R, Hattenbach LO, Pfeilschifter J, Pfeilschifter W.
Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy.
Invest Ophthalmol Vis Sci. 2018 Feb 1.

Joshi SS, Tandukar B, Castaneda M, Jiang S, Diwakar G, Hertzano RP, Hornyak TJ.
Characterization of a new, inducible transgenic mouse model with GFP expression in melanocytes and their precursors.
Gene Expr Patterns. 2017 Oct 21.

Romanelli F, Corbo A, Salehi M, Yadav MC, Salman S, Petrosian D, Rashidbaigi OJ, Chait J, Kuruvilla J, Plummer M, Radichev I, Margulies KB, Gerdes AM, Pinkerton AB, Millán JL, Savinov AY, Savinova OV.
Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia.
PLoS One. 2017 Oct 12.

Schwalm S, Beyer S, Frey H, Haceni R, Grammatikos G, Thomas D, Geisslinger G, Schaefer L, Huwiler A, Pfeilschifter J.
Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction.
Am J Pathol. 2017 Aug 12.

Viswambharan H, Yuldasheva NY, Sengupta A, Imrie H, Gage MC, Haywood NJ, Walker AM, Skromna A, Makova N, Galloway SL, Shah P, Sukumar P, Porter KE, Grant PJ, Shah AM, Santos CX, Li J, Beech DJ, Wheatcroft S, Cubbon RM, Kearney MT.
Selective Enhancement of INS Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop.
Circ Res. 2016 Dec 5.

Bondulich MK, Guo T, Meehan C, Manion J, Rodriguez Martin T, Mitchell JC, Hortobagyi T, Yankova N, Stygelbout V, Brion JP, Noble W, Hanger DP.
Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate.
Brain. 2016 Jun 12.

Wang J, Zhang X, Wang P, Wang X, Farris AB 3rd, Wang Y.
Lessons learned using different mouse models during space radiation-induced lung tumorigenesis experiments.
Life Sci Space Res (Amst). 2016 Jun.

Savinov AY, Salehi M, Yadav MC, Radichev I, Millán JL, Savinova OV.
Transgenic Overexpression of Tissue-Nonspecific Alkaline Phosphatase (TNAP) in Vascular Endothelium Results in Generalized Arterial Calcification.
J Am Heart Assoc. 2015 Dec 16.

Sheen CR, Kuss P, Narisawa S, Yadav MC, Nigro J, Wang W, Chhea TN, Sergienko EA, Kapoor K, Jackson MR, Hoylaerts MF, Pinkerton AB, O'Neill WC, Millán JL.
Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification.
J Bone Miner Res. 2015 May.

López-Soldado I, Zafra D, Duran J, Adrover A, Calbó J, Guinovart JJ.
Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model.
Diabetes. 2015 Mar.

Iqbal AJ, McNeill E, Kapellos TS, Regan-Komito D, Norman S, Burd S, Smart N, Machemer DE, Stylianou E, McShane H, Channon KM, Chawla A, Greaves DR
Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.
Blood. 2014 Oct 9.

Plucińska K, Crouch B, Koss D, Robinson L, Siebrecht M, Riedel G, Platt B
Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes.
J Neurosci. 2014 Aug 6.

McNeill E, Iqbal AJ, Patel J, White GE, Regan-Komito D, Greaves DR, Channon KM
Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis.
J Mol Med (Berl). 2014 Aug 1.

Rosendahl A, Niemann G, Lange S, Ahadzadeh E, Krebs C, Contrepas A, van Goor H, Wiech T, Bader M, Schwake M, Peters J, Stahl R, Nguyen G, Wenzel UO
Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice.
Lab Invest. 2014 Aug.

LeBlanc AC, Ramcharitar J, Afonso V, Hamel E, Bennett DA, Pakavathkumar P, Albrecht S
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.
Cell Death Differ. 2014 May 21.

Clarke SE, Kang JX, Ma DW
The iFat1 transgene permits conditional endogenous n-3 PUFA enrichment both in vitro and in vivo.
Transgenic Res. 2014 Mar 13.

Imudia AN, Wang N, Tanaka Y, White YA, Woods DC, Tilly JL.
Comparative gene expression profiling of adult mouse ovary-derived oogonial stem cells supports a distinct cellular identity.
Fertil Steril. 2013 Nov.

Winkelmann A, Maggio N, Eller J, Caliskan G, Semtner M, Häussler U, Jüttner R, Dugladze T, Smolinsky B, Kowalczyk S, Chronowska E, Schwarz G, Rathjen FG, Rechavi G, Haas CA, Kulik A, Gloveli T, Heinemann U, Meier JC.
Changes in neural network homeostasis trigger neuropsychiatric symptoms.
J Clin Invest. 2014 Jan 16.

Dart DA, Waxman J, Aboagye EO, Bevan CL.
Visualising androgen receptor activity in male and female mice.
PLoS One. 2013 Aug 7.

Gulbins E, Palmada M, Reichel M, Lüth A, Böhmer C, Amato D, Müller CP, Tischbirek CH, Groemer TW, Tabatabai G, Becker KA, Tripal P, Staedtler S, Ackermann TF, van Brederode J, Alzheimer C, Weller M, Lang UE, Kleuser B, Grassmé H, Kornhuber J.
Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs.
Nat Med. 2013 Jul.

Mühle C, Huttner HB, Walter S, Reichel M, Canneva F, Lewczuk P, Gulbins E, Kornhuber J.
Characterization of Acid sphingomyelinase activity in human cerebrospinal fluid.
PLoS One. 2013 May 2.

Ehrmann I, Dalgliesh C, Liu Y, Danilenko M, Crosier M, Overman L, Arthur HM, Lindsay S, Clowry GJ, Venables JP, Fort P, Elliott DJ.
The Tissue-Specific RNA Binding Protein T-STAR Controls Regional Splicing Patterns of Neurexin Pre-mRNAs in the Brain.
PLoS Genet. 2013 Apr.

Ryan D, Koss D, Porcu E, Woodcock H, Robinson L, Platt B, Riedel G.
Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent.
Cell Mol Life Sci. 2013 Mar 28.

Imrie H, Viswambharan H, Sukumar P, Abbas A, Cubbon RM, Yuldasheva N, Gage M, Smith J, Galloway S, Skromna A, Rashid ST, Futers TS, Xuan S, Gatenby VK, Grant PJ, Channon KM, Beech DJ, Wheatcroft SB, Kearney MT.
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.
Diabetes. 2012 Sep.

Duran J, Tevy MF, Garcia-Rocha M, Calbó J, Milán M, Guinovart JJ.
Deleterious effects of neuronal accumulation of glycogen in flies and mice.
EMBO Mol Med. 2012 Aug.

Platt B, Drever B, Koss D, Stoppelkamp S, Jyoti A, Plano A, Utan A, Merrick G, Ryan D, Melis V, Wan H, Mingarelli M, Porcu E, Scrocchi L, Welch A, Riedel G.
Abnormal Cognition, Sleep, EEG and Brain Metabolism in a Novel Knock-In Alzheimer Mouse, PLB1.
PLoS One. 2011 Nov 11.

Needham LA, Davidson AH, Bawden LJ, Belfield A, Bone EA, Brotherton DH, Bryant S, Charlton MH, Clark VL, Davies SJ, Donald A, Day FA, Krige D, Legris V, McDermott J, McGovern Y, Owen J, Patel SR, Pintat S, Testar RJ, Wells GM, Moffat D, Drummond AH.
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
J Pharmacol Exp Ther. 2011 Oct.

van den Born E, Vågbø CB, Songe-Møller L, Leihne V, Lien GF, Leszczynska G, Malkiewicz A, Krokan HE, Kirpekar F, Klungland A, Falnes PØ.
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nat Commun. 2011 Feb 1.


Zhichao Ni, Lingxia Lyu, Hui Gong, Luping Du, Zuoshi Wen, Hua Jiang, Hao Yang, Yanhua Hu, Bohuan Zhang, Qingbo Xu, Xiaogang Guo, Ting Chen.
Multilineage commitment of Sca-1+ cells in reshaping vein grafts.
Theranostics. 2023 Apr 1

Carl J May, Musleeha Chesor, Sarah E Hunter, Bryony Hayes, Rachel Barr, Tim Roberts, Fern A Barrington, Louise Farmer, Lan Ni, Maisie Jackson, Heidi Snethen, Nadia Tavakolidakhrabadi, Max Goldstone, Rodney Gilbert, Matt Beesley, Rachel Lennon, Rebecca Foster, Richard Coward, Gavin I Welsh, Moin A Saleem.
Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events.
Kidney Int. 2023 Mar 20

Marc L Purazo, Ryan J Ice, Rahul Shimpi, Mark Hoenerhoff, Elena N Pugacheva.
NEDD9 Overexpression Causes Hyperproliferation of Luminal Cells and Cooperates with HER2 Oncogene in Tumor Initiation: A Novel Prognostic Marker in Breast Cancer.
Cancers (Basel). 2023 Feb 9

Chiahsuan Chin, Ranjithkumar Ravichandran, Kristina Sanborn, Timothy Fleming, Stephen B Wheatcroft, Mark T Kearney, Sofya Tokman, Rajat Walia, Michael A Smith, David J Flint, Thalachallour Mohanakumar, Ross M Bremner, Angara Sureshbabu.
Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.
Cell Rep Med. 2023 Feb 9

Jun W Kim, Julie H Ko, Julien Sage.
DLL3 regulates Notch signaling in small cell lung cancer.
iScience. 2022 Nov 16

Julia Leschik, Antonietta Gentile, Cigdem Cicek, Sophie Péron, Margaryta Tevosian, Annika Beer, Konstantin Radyushkin, Anna Bludau, Karl Ebner, Inga Neumann, Nicolas Singewald, Benedikt Berninger, Volkmar Lessmann, Beat Lutz.
Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis
Prog Neurobiol. 2022 Jul 21

Yu Ting Ong, Jorge Andrade, Max Armbruster, Chenyue Shi, Marco Castro, Ana S H Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm, Joseph Lim, Shuichi Watanabe, Stefan Guenther, Andre Schneider, Francesca Zanconato, Manuel Kaulich, Duojia Pan, Thomas Braun, Holger Gerhardt, Alejo Efeyan, Peter Carmeliet, Stefano Piccolo, Ana Rita Grosso, Michael Potente.
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth
Nat Metab. 2022 Jun

Francesca Mateo, Zhengcheng He, Lin Mei, Gorka Ruiz de Garibay, Carmen Herranz, Nadia García, Amanda Lorentzian, Alexandra Baiges, Eline Blommaert, Antonio Gómez, Oriol Mirallas, Anna Garrido-Utrilla, Luis Palomero, Roderic Espín, Ana I Extremera, M Teresa Soler-Monsó, Anna Petit, Rong Li, Joan Brunet, Ke Chen, Susanna Tan, Connie J Eaves, Curtis McCloskey, Razq Hakem, Rama Khokha, Philipp F Lange, Conxi Lázaro, Christopher A Maxwell, Miquel Angel Pujana.
Modification of BRCA1-associated breast cancer risk by HMMR overexpression.
Nat Commun. 2022 Apr 7

Isabel Fernández-Pisonero, Laura Clavaín, Javier Robles-Valero, L Francisco Lorenzo-Martín, Rubén Caloto, Blanca Nieto, Carmen García-Macías, Clara L Oeste, Manuel Sánchez-Martín, Antonio Abad, Alejandro Hortal, Dolores Caballero, Marcos González, Mercedes Dosil, Balbino Alarcón, Xosé R Bustelo.
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
Cell Rep. 2022 Mar 15

Alejandro M Hortal, Clara L Oeste, Claudia Cifuentes, Miguel Alcoceba, Isabel Fernández-Pisonero, Laura Clavaín, Rut Tercero, Pilar Mendoza, Verónica Domínguez, Marta García-Flores, Belén Pintado, David Abia, Carmen García-Macías, Almudena Navarro-Bailón, Xosé R Bustelo, Marcos González, Balbino Alarcón.
Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia
Mol Cancer. 2022 Feb 4

Valentina Poli, Marco Di Gioia, Martha Sola-Visner, Francesca Granucci, Andrew L Frelinger 3rd, Alan D Michelson, Ivan Zanoni.
Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia
Immunity. 2021 Dec 24

Ewoud R E Schmidt, Hanzhi T Zhao, Jung M Park, Mario Dipoppa, Mauro M Monsalve-Mercado, Jacob B Dahan, Chris C Rodgers, Amélie Lejeune, Elizabeth M C Hillman, Kenneth D Miller, Randy M Bruno, Franck Polleux.
A human-specific modifier of cortical connectivity and circuit function.
Nature. 2021 Nov

Yannick Fotio, Kwang-Mook Jung, Francesca Palese, Andre Obenaus, Alex Mabou Tagne, Lin Lin, Tarif Ibne Rashid, Romario Pacheco, Amandine Jullienne, Jade Ramirez, Marco Mor, Gilberto Spadoni, Cholsoon Jang, Andrea G Hohmann, Daniele Piomelli.
NAAA-regulated lipid signaling governs the transition from acute to chronic pain.
Sci Adv. 2021 Oct 22

Christian Smolka, Delia Schlösser, Catherine Hohnloser, Xavier Bemtgen, Caterina Jänich, Laura Schneider, Julien Martin, Dietmar Pfeifer, Martin Moser, Peter Hasselblatt, Christoph Bode, Sebastian Grundmann, Franziska Pankratz.
MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice.
Mol Med. 2021 Sep 6

Dustin J Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J Willis, Kathryn Gilroy, Alexander P Raven, Lynn Mcgarry, Johanna I Englund, Anna T Webb, Sandra Scharaw, Nadia Nasreddin, Michael C Hodder, Rachel A Ridgway, Emma Minnee, Nathalie Sphyris, Ella Gilchrist, Arafath K Najumudeen, Beatrice Romagnolo, Christine Perret, Ann C Williams, Hans Clevers, Pirjo Nummela, Marianne Lähde, Kari Alitalo, Ville Hietakangas, Ann Hedley, William Clark, Colin Nixon, Kristina Kirschner, E Yvonne Jones, Ari Ristimäki, Simon J Leedham, Paul V Fish, Jean-Paul Vincent, Pekka Katajisto, Owen J Sansom.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Nature. 2021 Jun

Talat H Malik, Daniel P Gitterman 2, Deborah P Lavin, Hannah J Lomax-Browne, E Christina Hiemeyer, Linda B Moran, Katharina Boroviak, H Terence Cook, Alyssa C Gilmore, Mawj Mandwie, Amina Ahmad, Ian E Alexander, Grant J Logan, Kevin J Marchbank, Allan Bradley, Matthew C Pickering.
Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.
Proc Natl Acad Sci U S A. 2021 Mar 30

Jumpei Kondo, Won Jae Huh, Jeffrey L Franklin, Michael C Heinrich, Brian P Rubin, Robert J Coffey.
A smooth muscle-derived, Braf-driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell-of-origin.
J Pathol. 2020 Dec

Silvia Pontis, Francesca Palese, Maria Summa, Natalia Realini, Massimiliano Lanfranco, Claudia De Mei, Daniele Piomelli.
N-Acylethanolamine Acid Amidase contributes to disease progression in a mouse model of multiple sclerosis.
Pharmacol Res. 2020 Oct

Enrique Calvo, Sara Cogliati, Pablo Hernansanz-Agustín, Marta Loureiro-López, Adela Guarás, Rafael A Casuso, Fernando García-Marqués, Rebeca Acín-Pérez, Yolanda Martí-Mateos, J C Silla-Castro, Marta Carro-Alvarellos, Jesús R Huertas, Jesús Vázquez, J A Enríquez.
Functional role of respiratory supercomplexes in mice: SCAF1 relevance and segmentation of the Q pool.
Sci Adv. 2020 Jun 24

Ravit Gabay Yehezkely, Shelly Zaffryar-Eilot, Anna Kaganovsky, Nurit Fainshtain Malka, Rohtem Aviram, Ido Livneh, Peleg Hasson.
Intracellular Role for the Matrix-Modifying Enzyme Lox in Regulating Transcription Factor Subcellular Localization and Activity in Muscle Regeneration.
Dev Cell. 2020 May 18.

Vorbach S, Gründer A, Zhou F, Koellerer C, Jutzi JS, Simoni M, Riccetti L, Valk PJ, Sanders MA, Müller-Tidow C, Nofer JR, Pahl HL, Potì F.
Enhanced expression of the sphingosine-1-phosphate-receptor-3 causes acute myelogenous leukemia in mice.
Leukemia. 2020 Mar.

Carlos Vicente-Gutierrez, Nicoló Bonora, Veronica Bobo-Jimenez, Daniel Jimenez-Blasco, Irene Lopez-Fabuel, Emilio Fernandez, Charlene Josephine, Gilles Bonvento, Jose A Enriquez, Angeles Almeida, Juan P Bolaños.
Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour.
Nat Metab. 2019 Feb.

Lu L, Marisetty A, Liu B, Kamal MM, Gumin J, Veo B, Cai Y, Kassem DH, Weng C, Maynard ME, Hood KN, Fuller GN, Pan ZZ, Cykowski MD, Dash PK, Majumder S.
REST overexpression in mice causes deficits in spontaneous locomotion.
Sci Rep. 2018 Aug 14.

Vanden Bempt M, Demeyer S, Broux M, De Bie J, Bornschein S, Mentens N, Vandepoel R, Geerdens E, Radaelli E, Bornhauser BC, Kulozik AE, Meijerink JP, Bourquin JP, de Bock CE, Cools J.
Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.
Cancer Cell. 2018 Aug 13.

Jones T, Jones PL.
A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy.
PLoS One. 2018 Feb 7.

van de Beek MC, Dijkstra IM, van Lenthe H, Ofman R, Goldhaber-Pasillas D, Schauer N, Schackmann M, Engelen-Lee JY, Vaz FM, Kulik W, Wanders RJ, Engelen M, Kemp S.
C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man.
PLoS One. 2016 Apr 28.

Sportoletti P, Varasano E, Rossi R, Bereshchenko O, Cecchini D, Gionfriddo I, Bolli N, Tiacci E, Intermesoli T, Zanghì P, Masciulli A, Martelli MP, Falzetti F, Martelli MF, Falini B.
The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.
Blood. 2013 Apr 25.

van den Born E, Vågbø CB, Songe-Møller L, Leihne V, Lien GF, Leszczynska G, Malkiewicz A, Krokan HE, Kirpekar F, Klungland A, Falnes PØ.
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nat Commun. 2011 Feb 1.

Follow these links if you are looking for another Knockin mouse model or customized mouse model.