Efficacy
Efficacy testing is a critical step in drug development, assessing whether a drug candidate achieves its intended effect at various doses.
Efficacy testing is a critical step in drug development, assessing whether a drug candidate achieves its intended effect at various doses.
If you have completed the in vitro testing of your lead compound, and you are looking for the ideal in vivo preclinical model toanalyze the efficacy of your construct, genOway can help you with the next steps.
Performing in vivo preclinical drug efficacy tests is essential to validate your drug candidate and collect key data for IND-approval.This step can help you:
Selecting the right preclinical model is essential for a successful transition to clinical trials. It ensures your results are relevant tohuman biology and helps avoid costly delays. Inappropriate model choices—such as using wild-type or mismatched humanizedmice—can lead to the premature rejection of promising drug candidates. For instance, choosing mice that do not express the correctlevels of your drug target in the right cells, could lead to the under-representation of a drug’s efficacy.
Finding the right model is essential to help you move seamlessly to clinical trials, ensuring that your results are translatable tohumans, and helping you save time.
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Having comprehensive background information is essential for selecting the right model for yourresearch needs. Understanding your drug target, its expression profile, and the mechanism ofaction—along with the associated signalling pathway—allows us to recommend the most suitablemodel aligned with your needs. Additionally, by discussing with us your questions such as in whichcells your target protein is expressed, and whether the expression is constant, it will allow us togive you a better-informed guidance. You can contact us and talk with our scientific experts - wewill be happy to discuss your data and ensure that we provide you with the most appropriatemodel for your research.
To help you choose the best model for your efficacy test, we may ask you some of the following questions:
We offer a diverse portfolio of preclinical models designed to support your research goals. Thesemodels can be used independently or in combination to enhance and accelerate your studies. Theyare available off-the-shelf through our Catalog Models, or can be custom-developed to meet yourspecific requirements through our Customized Models.
Our selection of catalog models includes different types of models useful for efficacy assays.
Target-specific humanized models
A wide range of target specific humanized strains is available and ready for purchase. These models areimmunocompetent, and display a physiological expression of the human target. Some of the modelspresent in our catalog include:
Our humanized mouse models can be used for syngeneic studies, for which there is available a complementarycatalog of cell lines.
As part of our catalog, we also provide humanized mouse models with a human immune system (HIS), such as thegenO-BRGSF-HIS and genO-BRGSF-A2-HIS models. Given their extended lifespan, functional human myeloid andlymphoid compartments and permissiveness to PDX and CDX engraftments, these models are ideal for efficacyassessment of immunotherapies targeting myeloid and lymphoid cells, as shown in the poster presented byMacomics and published by IGM Biosciences.
In our vast portfolio you can also find immunodeficient rodents. If you are testing cell therapies such as CAR-T cells,or if you want to test new compounds for chemotherapy, then our immunodeficient models can be useful for you.They support PDX and CDX engraftment and can develop metastasis, as well as allowing longer experimentaltimeframes due to their extended longevity.
Our team of scientific experts is here to support you in defining, designing, and optimizing yourexperiments to ensure the best possible outcomes. You’ll be able to discuss with our experiencedresearchers who can collaborate with you on your study design, data interpretation, and strategicplanning—before, during, and after project execution. We view ourselves as active partners in yourresearch, committed to helping your project succeed.
In order to maximize the output of your experiments, and based on our knowledge of thespecifications of each model, our scientists will be able to guide you regarding topics such as:
You can contact us at any moment during the process - we are here to help and we take time to dedicate to you and toyour needs.
If you do not have the time or the right facilities to perform your next experiments, we candiscuss to see if they can be done at genOway thanks to our preclinical studies platform, or wecan help you choose a trusted Contract Research Organization (CROs) to perform yourexperiments, so you can focus on advancing your discoveries.
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