genO-hTFRC mice help assess the efficacy of antibodies targeting brain cells
Lundbeck has demonstrated that the genO-hTFRC model can be used to assess the efficacy of antibodies that target proteins expressed in brain cells, such as BACE1.
Efficacy assessment of anti-BACE1 or anti-TFRC/anti-BACE1 antibodies in genO-hTFRC mice
Adapted from Sônego et al., poster presented at AACR 2024
What sets the genO-hTFRC mouse model apart?
- Physiological regulation and expression pattern of human TFRC
- Lack of expression of the murine target gene
- Fully functional mouse immune system
- Available on C57BL/6N genetic background
Discover our catalog of genO-hTFRC upgrades
In order to expand the range of applications of our genO-hTFRC mouse, this model has been intercrossed with several other models:
- genO-hTFRC/hFcγR — to increase translatability of Fc-dependent antibodies that target the CNS
- genO-hTFRC/hSA/hFcRn — to improved PK/PD analysis of antibodies with extended half-life
Improve the delivery of therapeutics aiming to cross the blood-brain barrier with the genO-hTFRC mouse model
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