Applications of the hTFRC mouse model

Useful applications for researchers working on different biomedical fields, such as neuroscience, immuno-oncology and inflammation:

  • Improve the delivery of therapeutic agents aiming to cross the blood-brain barrier (BBB), via human transferrin receptor (TFRC) binding and test their efficacy
  • Assess the efficacy of immunotherapies in cancers that overexpress TFRC (CD71, TfR1)
  • Evaluate the in vivo PK profile and toxicity of TFRC-binding therapeutics

Features

  • Physiological regulation and expression pattern of human TFRC
  • Lack of expression of the murine target gene
  • Fully functional mouse immune system
  • Available on C57BL/6N genetic background

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Related resources and publications

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hTFRC

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Preclinical humanized TFRC mouse model

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